|
KMID : 0377519840090020149
|
|
Chung-Ang Journal of Medicine
1984 Volume.9 No. 2 p.149 ~ p.154
|
|
|
Effect of Korean Snake Venom on the Frog Ventricular Action Potential
|
|
Chung Hae-Sung
Bang Hyo-Weon
Uhm Dae-Yong
Rhee Sang-Don
|
|
|
Abstract
|
|
|
|
Action potential of a frog ventricular cell was studied by conventional 3M KCI glass microelectrodes to investigate the effect of freeze-dried Korean snake venom. Following results were obtained; 1. Time to repolarize 50% of its action potential increased from 756±26mS to 796±17mS. 2. The notch which would be seen after the fast depolarization disappeared and the overshoot potential significantly decreased from 24.4±0.9㎷ to 17.8±2.3㎷. 3. Positive depolarization rate (dV/dt max) decreased from 22.8±0.8V/s to 18.8±0.8V/s. 4. Resting membrane potential was -95±3.0㎷ and showed little change. Above results would be interpreted that the Korean snake venom blocked the fast sodium channel and slow calcium channel simultaneously to reduce the contractility and activation of potassium channel which could result the prolongation of action potential duration.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|